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Role of Cystatin-C in periodontal health and disease

EVALUATION OF CYSTATIN â?? C PROTEIN & CST3 GENE EXPRESSION IN PERIODONTAL HEALTH AND DISEASE: AN OBSERVATIONAL STUDY

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2020/03/023926
Enrollment
50
Registered
2020-03-12
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

None listed

Sponsors

Jeneffar Roselin C
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Group ɪ - Periodontally healthy subjects 1) Systemically and periodontally healthy subjects planning for extraction due to orthodontic treatment. Group ɪɪ - Chronic periodontitis subjects 2) Patients with Stage III / IV periodontitis exhibiting sites with PPD >= 6 mm, CAL >= 5 mm (According to 2017 World Workshop on Classification of Periodontal Diseases and Conditions).

Exclusion criteria

Exclusion criteria: 1) Patients with systemic condition or diseases influencing the course of periodontitis including renal diseases and Alzheimerâ??s disease. 2) History of periodontal treatment within the previous six months. 3) Antimicrobial therapy, immunosuppressants within the previous six months. 4) Smokers and alcoholics. 5) Pregnancy and lactation.

Design outcomes

Primary

MeasureTime frame
To compare the expression of Cystatin-C gene (CST3) in healthy and periodontitis subjects using real time PCRTimepoint: at baseline—

Countries

India

Contacts

Public ContactDeepa Ponnaiyan

SRM Dental college and hospitals, Ramapuram

jeneffar2010@gmail.com8939177390

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 15, 2026