Effect of two different drugs on heart rate and blood pressure during keyhole nose surgery

Effect of Dexmedetomidine versus Esmolol on intraoperative haemodynamics in functional endoscopic sinus surgery

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/03/023914

Enrollment

Registered

2020-03-12

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J321- Chronic frontal sinusitis

Interventions

Intervention1: Esmolol: loading dose of esmolol iv over 10 minutes at 0.5 mg/Kg, followed by infusion rate of 0.4 mg/Kg to 0.8 mg/Kg/hour Control Intervention1: Dexmedetomidine: Dexmedetomidine iv at

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1,2 patients undergoing Functional endoscopic sinus surgery

Exclusion criteria

Exclusion criteria: 1. Known allergy to alpha-2 agonist &Î² blocker 2.Patient with hepatic and renal dysfunction 3. COPD & Asthmatic patients 4.Patients with heart block

Design outcomes

Primary

Measure	Time frame
To compare the effect of Dexmedetomidine v/s Esmolol on intraoperative heart rate response in Functional endoscopic sinus surgeryTimepoint: baseline, 1 min before intubation, 1 min after intubation, before the start of infusion with esmolol/dexmedetomidine followed by every 10minutes till the end of surgery	—

Secondary

Measure	Time frame
a)To compare the effect on intraoperative mean arterial blood pressure b)To assess quality of surgical field c)Postoperative sedation score d)Postoperative painTimepoint: a) Changes in mean arterial pressure will be monitored 10 min after intubation then every 15 minutes b) Quality of surgical field will be assessed at end of surgery c)Sedation and postoperative pain will be assessed immediately after extubation(0 mins), 30 and 60 minutes post operatively	—

Measure

Time frame

a)To compare the effect on intraoperative mean arterial blood pressure b)To assess quality of surgical field c)Postoperative sedation score d)Postoperative painTimepoint: a) Changes in mean arterial pressure will be monitored 10 min after intubation then every 15 minutes b) Quality of surgical field will be assessed at end of surgery c)Sedation and postoperative pain will be assessed immediately after extubation(0 mins), 30 and 60 minutes post operatively

—

Countries

India

Contacts

Public ContactDr Radhika R

Amrita Institute of Medical Sciences

rajgokulam70@gmail.com04842806162

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026