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A study comparing individualized versus fixed lung pressures during anaesthesia in patients undergoing keyhole gynecological operations.

A comparative study of optimum versus fixed positive end expiratory pressure on incidence of postoperative lung atelectasis in patients undergoing laparoscopic gynecological surgery : A Double Blinded Randomised Control Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/03/023896
Enrollment
82
Registered
2020-03-11
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N948- Other specified conditions associated with female genital organs and menstrual cycle

Interventions

Intervention1: PEEP titration based on maximum lung compliance in laparoscopic gynecological surgery: Lung recruitment in pressure control mode is followed by optimum PEEP ventilatory setting based on

Sponsors

All India Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult female patients (18 to 65 years of age) of ASA 1/2 who undergo elective major laparoscopic gynecological surgery(defined by a duration of 2 hours or more) under general anaesthesia and in Trendelenburg position (20 degree - 30 degree)

Exclusion criteria

Exclusion criteria: Patient refusal to participate in the study, known COPD or other chronic diseases, Known deformity of chest wall or thoracic spine, pre- existing significant cardiac renal and hepatic diseases, intraoperative massive blood loss(blood loss >40 ml/kg) or massive transfusion ( >8 unit PRBC transfusion during surgery p), patients with history of previous thoracic surgery, BMI >30kg/sq.m or <18 kg/sq.m

Design outcomes

Primary

MeasureTime frame
Compare magnitude of postoperative lung atelectasis assessed by modified lung ultrasound score between optimum PEEP group and fixed PEEP groupTimepoint: 15 minutes after extubation—

Secondary

MeasureTime frame
1) Correlation of modified lung ultrasound score with a) PaO2/FiO2 ratio b) Body mass index(BMI) c) Alveolar- arterial oxygen gradient d) Duration of pneumoperitoneum 2) incidence of intraoperative hypotension and bradycardia, change in driving pressure after deflation of pneumoperitoneum at the end of surgery, number of patients requiring supplemental oxygen to maintain SaO294% in both groups (optimum PEEP group and fixed PEEP group)Timepoint: Intraoperative time plus postoperative period(30 minutes after extubation to maximum till 24 hours)—

Countries

India

Contacts

Public ContactDr Rakesh Kumar

ALL India Institute of Medical Sciences

drrakesh.kumar.akb@gmail.com07838043581

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026