Health Condition 1: D561- Beta thalassemia
Conditions
Interventions
Intervention1: Administration of folic acid in different doses: Folic acid will be administered as - 5mg in Group 1, 2.5mg in Group 2 and 5mg per week in Group 3
Control Intervention1: Folic acid in d
Sponsors
University college of Medical Sciences and Guru Teg Bahadur Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Transfusion dependent thalassemia major patients aged 5 to 18 years will be included
Exclusion criteria
Exclusion criteria: Patients deficient in folate and Vit. B12, splenectomized patients, patients with chronic liver disease, Hepatitis B or C infection, patients taking medicines affecting folate metabolism (cotrimoxazole or methotrexate) will be excluded
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of children with folate excess( serum folate more than or equal to 20ng/ml) after 6 months of therapyTimepoint: 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood transfusion requirement over 6 monthsTimepoint: 6 months;Mean corpuscular volume , Reticulocyte count after 6 months of therapyTimepoint: 6 months of therapy;Proportion of children with folate deficiency (less than 2 ng/ml)Timepoint: 6 months;RBC and serum folate levels and homocysteine levels after 6 months of therapyTimepoint: 6 months | — |
Countries
India
Contacts
Public ContactDr Titiksha Agrawal
Guru Teg Bahadur Hospital
Outcome results
None listed