Health Condition 1: G20- Parkinsons disease
Conditions
Interventions
Intervention1: real TMS: 7 days. 2 hour rTMS/ day and 2 hour evaluation/ assessment session on first and last day.
Control Intervention1: Sham TMS: 7 days. 2 hour rTMS/ day and 2 hour evaluation/ asse
Sponsors
ICMR Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1. Diagnosis of clinically definite PD, defined by UKPD brain bank clinical and diagnostic criteria. With presence of at least 1 out of 3 cardinal motor features of PD (resting tremor, rigidity, and postural impairment like bradykinesia); 2. PWP of both gender with H&Y stage from 1 to 2.5 3. PWP between age 45 to 75 on stable medication for at least 30 days. 4. Controls: Healthy adults of both gender aged 45-60
Exclusion criteria
Exclusion criteria: 1. Features suggestive of other causes of Parkinsonism/ Parkinson-plus syndromes; 2. History of ICSOL (intracranial space occupying lesion) or brain surgeries, significant headaches, epilepsy or seizure disorder, mass lesions, or major head trauma leading to loss of consciousness of any length; 3. Family (1st degree relatives) history of epilepsy; 4. Presence of contraindications for functional magnetic resonance imaging (fMRI) like metal implants, and claustrophobia; 5. History of schizophrenia, schizoaffective disorder, other psychosis, rapid-cycling bipolar illness, alcohol/drug abuse within the past year; 6. Need for rapid clinical response due to conditions such as psychosis, or suicide tendency; 7. PWP with uncontrolled hypertension and diabetes and other uncontrolled medical illness. PWP with hypertension or diabetes would be included only if they are stable on medication for last six months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| UPDRS; LED; PDQ 39Timepoint: Day 0 Day 7 | — |
Secondary
| Measure | Time frame |
|---|---|
| MRCP, r-fMRITimepoint: Day 0 Day 7 | — |
Countries
India
Contacts
Public ContactPriyanka Bhat
AIIMS
Outcome results
None listed