Botulinum toxin injection vs Surgery for chronic anal fissure

Comparative Study of Botulinum Toxin Injection and Lateral Internal Sphincterotomy in the treatment of Chronic Anal Fissure

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/03/023878

Enrollment

Registered

2020-03-11

Start date

Unknown

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K601- Chronic anal fissure

Interventions

Intervention1: Botulinum Toxin Injection: 20 IU injection into anal sphincter. Single dose Control Intervention1: Lateral Internal Sphincterotomy: Surgical procedure for chronic anal fissure

Eligibility

Inclusion criteria

Inclusion criteria: Chronic anal fissure

Exclusion criteria

Exclusion criteria: Acute fissure in ano,hemorrhoids, fistula in ano, allergic reaction to Botulinum toxin, diabetics, hypertensives

Design outcomes

Primary

Measure	Time frame
Healing of fissure seen by formation of stable scarTimepoint: 6 weeks 1 month 3 months	—

Secondary

Measure	Time frame
Measurement of incontinence by calculating Wexner scaleTimepoint: 6 weeks 3 months	—

Countries

India

Contacts

Public ContactS Maniselvi

Madras Medical College

drmaniselvi@yahoo.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026