Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Effect of Oral Gabapentin on hemodynamic parameters during laryngoscopy and endotracheal intubation.: On the morning of surgery, Capsule Gabapentin 700mg (1 capsule of 400 mg and 1 caps
Sponsors
Dr Deepak Khare
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients undergoing elective surgeries requiring general anaesthesia with endotracheal intubation. 2.ASA 1 and 2 patients. 3.Patients aged 20-50 years of both sexes. 4.Patients having modified Mallampatti grade 1 and 2 score.
Exclusion criteria
Exclusion criteria: 1.Emergency surgeries. 2.ASA Grade 3 and 4 patients. 3.Patients with age less than 20 years and more than 50 years. 4.Patients with anticipated difficult airway. 5.Patient requiring more than 1 attempt for intubation or requiring additional assistance like external laryngeal manipulation, use of stylet, bougie etc. 6.Known history of allergy / sensitivity reaction to clonidine or gabapentin. 7.Patients with hypertension, diabetes mellitus, patient on beta blockers, anti convulsant or anti-psychotics. 8.Patients with history of- i.Cerebrovascular disease ii.Neurological disease iii.Respiratory disease iv.Ischemic heart disease v.Renal disease and Hepatic dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Which among oral clonidine and oral gabapentin causes a lesser degree of hemodynamic changes during laryngoscopy and intubation.Timepoint: Just prior to laryngoscopy, during intubation and immediately after intubation upto first five mins as T1, T2, T3, T4, T5 and then at 7th and 10th mins respectively. | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare side effects if any, arising due to the effect of study drugs.Timepoint: During laryngoscopy, endotracheal intubation and after endotracheal intubation at 1,2,3,4,5,7 and 10 mins respectively. | — |
Countries
India
Contacts
Public ContactDr Deepak Khare
Jawahar Lal Nehru Hospital And Research Centre
Outcome results
None listed