To check the effectiveness of a combination of coconut oil and probiotics on patients having denture stomatitis

A randomized clinical trial to assess and compare the effect of a combination of probiotics and Cocos nucifera oil with commercially available Candid mouth paint on the growth of Candida albicans in denture stomatitis patients.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/03/023805

Enrollment

112

Registered

2020-03-06

Start date

Unknown

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B370- Candidal stomatitis

Interventions

Intervention1: Combination of probiotics and coconut oil: Combining 5% coconut oil with 1 capsule of probiotics, which will be made as a paste and applied on the denture bearing area twice daily for 4

Eligibility

Inclusion criteria

Inclusion criteria: i. Completely edentulous patients ii. Previous denture wearers with denture stomatitis iii. Patients having denture stomatitis

Exclusion criteria

Exclusion criteria: i. Patients with a history of consumption of probiotics ii. Patients under any medication for systemic diseases iii. Patients using antifungal medicaments iv. Patients using mouthwashes v. Partially edentulous patients using removable partial denture prosthesis

Design outcomes

Primary

Measure	Time frame
The primary outcome will be reduction in the growth of candida organisms in patients using the new medicine. Quantification of fungal growth will be done using Colony Forming Units(CFU). the quantity of reduction cannot be specified.Timepoint: 4 weeks	—

Secondary

Measure	Time frame
Analysis of reduction in the growth of candida organisms in patients using the new medicine. Quantification of fungal growth will be done using Colony Forming Units(CFU). the quantity of reduction cannot be specified.Timepoint: 2 weeks	—

Countries

India

Contacts

Public ContactGayathri Krishnamoorthy

Manipal College of Dental Sciences

gayathri.km@manipal.edu8197768146

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026