A study to compare 2 medications-Phenylephrine and Norepinephrine to prevent fall in blood pressure caused after giving spinal anaesthesia in patients undergoing Caesarean section.

A prospective, randomized double-blinded study to compare Phenylephrine and Norepinephrine infusion to prevent hypotension following Subarachnoid block in patients undergoing Caesarean delivery.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/03/023761

Enrollment

102

Registered

2020-03-04

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O295- Other complications of spinal andepidural anesthesia during pregnancy

Interventions

Intervention1: Infusion of Norepinephrine: Infusion of Norepinephrine 25mcg/min ( titrated according to blood pressure ) will be given intravenously prophylactically after subarachnoid block. Infusion

Eligibility

Inclusion criteria

Inclusion criteria: Grade 3 and 4 as per Lucas classification of urgency of caesarean section Pregnant females undergoing Caesarean section under spinal anaesthesia Age 18-35 years ASA grade 2 Gestational age more than 37 weeks with singleton pregnancy

Exclusion criteria

Exclusion criteria: Not consenting for the study ASA grades 3,4 Body weight 100kgs Height 170cm Any pregnancy complications like pregnancy-induced hypertension, gestational diabetes,abruptio placenta, placenta previa Any medical diseases like Diabetes mellitus, Hypertension, Cardiac diseases, Severe anemia, Peripheral vascular diseases. Failed subarachnoid block Contraindication to Spinal Anaesthesia Patients on monoamine oxidase inhibitors and anti-depressants Spinal Deformities Diagnosed preoperative fetal compromise

Design outcomes

Primary

Measure	Time frame
To compare the incidence of post-spinal hypotension in women receiving phenylephrine versus norepinephrine infusion.Timepoint: Every minute after spinal anaesthesia upto delivery of newborn.	—

Secondary

Measure	Time frame
To compare incidences of maternal bradycardia, fetal acid-base balance, Apgar score and the requirements of vasopressor dosesTimepoint: Every minute after spinal anaesthesia upto delivery of newborn.	—

Countries

India

Contacts

Public ContactDr Mamta Sinha

AIIMS, RAIPUR

drmamta12@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026