Health Condition 1: N29- Other disorders of kidney and ureter in diseases classified elsewhere
Conditions
Interventions
Intervention1: Inj Propofol: Infusion of Inj Propofol at a dose of 150 to 200mcg/Kg/minute titrated to a Bispectral Index (BIS) between 40 to 60
Control Intervention1: Sevoflurane: Sevoflurane Inhalat
Sponsors
CHRISTIAN MEDICAL COLLEGE
Eligibility
Inclusion criteria
Inclusion criteria: All patients undergoing elective laparoscopic nephrectomy ASA 1 and 2
Exclusion criteria
Exclusion criteria: ASA 3 or more Allergic to local anaesthetics Serum creatinine >1.4mg/dl Psychiatric disorders Chronic opioid usage Steroid treatment Patient refusal
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the recovery profile measured by quality of recovery score 15(QoR-15), in patients receiving TIVA using propofol or Inhalational anaesthesia using sevoflurane for laparoscopic nephrectomy at 24 hours after surgeryTimepoint: 24 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative analgesic requirementTimepoint: Cumulattive analgesic use calculated at end of anaesthesia;To compare intraoperative vasopressor/ inotrope support requirement between two groups Timepoint: Total cumulative dose required from induction to extubation;To compare the incidence of postoperative nausea and vomiting (PONV)Timepoint: Number of episodes during the first 24 hours post operation;To compare the intra-operative hemodynamic profile.Timepoint: Intraoperative every 15 minutes from induction to extubation;To compare the patient satisfactionTimepoint: Postoperative 24 hours after extubation;To compare the recovery profile, measured by quality of recovery score 15 at 48-hours post operationTimepoint: 48 hours post operation;To compare the time to DRink (Time from extubation to the time at which the patient asks for oral fluids), time to EAt solids orally (Time from extubation to the time at which the patient asks for solid food) and the time to Mobilize with support (Time from extubation to the time at which the patient walks with support) (DREAM TIME)Timepoint: Time from extubation to completion of each task on demand.;To compare the total dose of morphine consumption at 24hours and 48 hoursTimepoint: 24 and 48 hours postoperative;To compare time taken to attain fitness for discharge from PACUTimepoint: Assessed every 10 minutes from extubation till Aldrette score greater than 8;To compare time taken to awaken from anaesthesiaTimepoint: Time of cessation of anaesthetic to time of obeying commands | — |
Countries
India
Contacts
Public ContactDR KAREN LIONEL
CHRISTIAN MEDICAL COLLEGE, VELLORE
Outcome results
None listed