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LOCAL ANAESTHETIC INDUCED MYOTOXICITY USING CPK ENZYME

A RANDOMISED CONTROLLED PROSPECTIVE STUDY OF LOCAL ANAESTHETIC INDUCED MYOTOXICITY IN TAP AND PEC BLOCK

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/03/023719
Enrollment
80
Registered
2020-03-03
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M628- Other specified disorders of muscle

Interventions

Intervention1: Myoticity in facial plane block TAP block PEC block: Bupivacaine induced myotoxicty using 0.25% of bupivacaine in TAP BLOCK and PEC block using CPK enzyme

Sponsors

VASUNDHARA RAKHI
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA I/II patients between 18 to 60 years of age undergoing elective mesh hernioplasty, simple or modified radical mastectomy will be included in the study.

Exclusion criteria

Exclusion criteria: Patient refusal for block, any history of bleeding disorder, local infection at the site of needle insertion, history of myodystrophies, history of endocrine disorders (hypothyroid, hyperthyroid, hyperparathyroid), electrolyte derangements (hyponatremia, hypokalemia, hypophosphatemia), history of obstructive sleep apnea, patients with direct injection into the muscle during block, allergic to local anaesthetics and patient on vasopressor will be excluded in the study.

Design outcomes

Primary

MeasureTime frame
To study the blood level of CPK enzyme level in patient undergoing simple/modified radical mastectomy and elective mesh hernioplasty with or without pectoral nerve block and transverse abdominis block respectively. Timepoint: 0 hour (baseline) 6 hours 12 hours

Secondary

MeasureTime frame
LOCAL anaesthetic induced myoticity using 0.25% bupivacaineTimepoint: Baseline 6 hours 12 hours

Countries

India

Contacts

Public Contactvasundhara rakhi

IGMC shimla

sonalikaushal33@gmail.com9888359167

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026