Health Condition 1: L237- Allergic contact dermatitis due toplants, except food
Conditions
Interventions
Intervention1: Patients of air borne contact dermatitis to parthenium: Cyclosporine 2.5 mg/kg for 12 weeks or complete remission, whichever is earlier
Control Intervention1: Not applicable: Not applic
Sponsors
Department of Science and Technology
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients of parthenium dermatitis with positive patch test to parthenium 2. Patients willing to undergo treatment and report for follow-up.
Exclusion criteria
Exclusion criteria: 1. Children, 2. Pregnant and lactating women. 3. Patients with active liver, kidney or hematological disorder. 4. History of hypersensitivity to cyclosporine. 5. Patients on immunosuppressive drugs within last 4 weeks. 6. Female patients who have not completed their family
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Improvement in pro- (TNF-α, IL-17 & IL-6) and anti-inflammatory serum cytokine (IL- 10 & TGF-beta) levels in patients with air-borne contact dermatitis to parthenium 2. Improvement in parthenium disease severity scoreTimepoint: During and after 12 weeks of therapy | — |
Secondary
| Measure | Time frame |
|---|---|
| To correlate the change in levels of pro and anti-inflammatory cytokines with clinical disease severity score and therapeutic response in these patients. Timepoint: After 12 weeks of therapy | — |
Countries
India
Contacts
Public ContactDr Neetu Bhari
All Institute of Medical Sciences
Outcome results
None listed