Health Condition 1: R00-R99- Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
Conditions
Interventions
Intervention1: Dexmedetomidine: Dexmedetomidine group: will receive 0.2 microgram/kg/hr to 1.2 microgram/kg/hr till extubation
Control Intervention1: Midazolam: Midazolam group will receive 0.06 mg/k
Sponsors
AIIMS Raipur
Eligibility
Inclusion criteria
Inclusion criteria: Children aged require sedation for >24 hours.
Exclusion criteria
Exclusion criteria: Children with unstable hemodynamics at the time of enrollment (Mean arterial blood pressure 2 vasoactive therapy support and/or requiring on going resuscitation) Children requiring mechanical ventilation for neuromuscular diseases Children severe central nervous system pathology like raised intracranial pressure irrespective of causes like cerebrovascular accident, status epilepticus. Children with developmental delay Children with evidence of myocardial dysfunction (ejection fraction Requiring dialysis irrespective of type at the time of enrollment. Received general anesthesia 24 hours prior to or planned after the start of study drug infusion Children with severe liver pathology like acute liver failure, hepatic encephalopathy,chronic liver disease etc. Children with trauma and burns as an admitting diagnosis Children ring neuromuscular blockade infusion other than for intubation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| length of mechanical ventilation. Timepoint: At extubation | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse of the study drugsTimepoint: After randomisation;Length of Hospital StayTimepoint: Discharge from hospital;Length of PICU stayTimepoint: Transfer from PICU to Ward;Number of intermittent dose requirements of opioids (Fentanyl and/or morphine) for sedation or analgesia Timepoint: after randomisation | — |
Countries
India
Contacts
Public ContactDR ATUL JINDAL
Department of pediatrics, AIIMS, Raipur, C.G.
Outcome results
None listed