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A clinical study which compares two different drugs in patients with severe tooth pain during and after root canal treatment

Comparative Evaluation of the efficacy of Prednisolone and Dexamethasone using two different delivery routes for the management of post-operative pain in patients with Symptomatic Irreversible Pulpitis - A Randomized, double blind study.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/02/023614
Enrollment
90
Registered
2020-02-27
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Group 1: Prednisolone group Subgroup 1A: Oral : Subgroup 1A: Oral 40 mg prednisolone tablet will be given half an hour before the start of procedure. Intervention2: Group 1: Prednisol

Sponsors

Dr Kokat Suhasini
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Systemically healthy patients (ASA I /II). 2.Patients who required endodontic treatment in lower teeth. 3.Vital teeth with no history of root canal therapy. 4.Patients who had tooth with clinical diagnosis of irreversible pulpitis. 5.Volunteers who suffered from moderate or severe pain. 6.Volunteers who signed a human subject committee approved consent form.

Exclusion criteria

Exclusion criteria: 1.Pregnant or lactating patients. 2.Patients who had taken analgesic or anti-inflammatory drugs within last 8hrs. 3.No volunteer under 18 years of age. 4.Any endocrine or infections disease or had any systemic disease that contraindicate endodontic therapy. 5.Active site of pathosis in the area of injection. 6.Moderate to advanced periodontal disease. 7.Non vital teeth (necrosis). 8.Any known sensitivity or other adverse reactions to any of the medication or materials used in the study.

Design outcomes

Primary

MeasureTime frame
All drugs used, decreases intra and postoperative painTimepoint: 2 hrs to 48 hrs

Secondary

MeasureTime frame
All drugs used, decreases postoperative painTimepoint: 6, 12 ,24 hrs

Countries

India

Contacts

Public ContactDr K Shekar

Sri Sai College of Dental Surgery

drshekarmds@gmail.com9985825481

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026