Health Condition 1: C50- Malignant neoplasm of breast Health Condition 2: C569- Malignant neoplasm of unspecifiedovary
Conditions
Interventions
None listed
Sponsors
Dr T M A Pai Fellowship
Eligibility
Inclusion criteria
Inclusion criteria: Known mutation in cancer susceptibility gene within the family Any patient with male breast cancer Personal history of breast cancer with one or more of following Early age of onset If diagnosed at Diagnosed at any age with: One or more close blood relative with breast cancer diagnosed at Two or more close blood relative with breast cancer at any age One or more close blood relative with invasive ovarian cancer Close male blood relative breast cancer.
Exclusion criteria
Exclusion criteria: Cancer individual without a family history Early death due to cancer or non-cancerous conditions Any psychological or genetic disorder with mental retardation Adoption and limited family size Patient not willing for genetic testing genetic counseling
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ï?? To identify the frequency types and genetic variants of germline mutations among the patient presenting with high risk of hereditary cancer by NGS Cancer risk assessment based on the genetic and non-genetic factors in patient and at-risk family memberTimepoint: 3years | — |
Secondary
| Measure | Time frame |
|---|---|
| Presence of other non-genetic confounding factors and comparison between incidence of nongenetic factor among the patient with average and high risk and To develop a genetic variation database for public health purposeTimepoint: 3years | — |
Countries
India
Contacts
Public ContactDr Karthik S Udupa
Manipal Academy of Higher Education
Outcome results
None listed