Is Quantitative Electroencephalography useful in predicting treatment outcome in patients with bipolar affective disorder currently having manic symptoms?

Quantitative Electroencephalography as a predictor of treatment Response to Divalproex sodium versus Lithium in Bipolar affective disorder

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/02/023566

Enrollment

Registered

2020-02-25

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F311- Bipolar disorder, current episodemanic without psychotic features

Interventions

Intervention1: QEEG: Patients will be analysed on QEEG and drugs will be given further comparsion will be done Control Intervention1: Divalproex sodium and lithium: Patients will be analysed on QEEG a

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patient or nominated representative willing for consent 2. Patients in the age group 18-45 3. Patients currently not on treatment with lithium or divalproex sodium, though might have received the same in the past (upto 2 weeks prior to the assessment) 4. Patients with YMRS score >12 & HAM-D 5. Patients diagnosed with Bipolar affective disorder with current episode mania or hypomania as per DSM 5 criteria

Exclusion criteria

Exclusion criteria: 1. Patients diagnosed with bipolar affective disorder current episode depressive with psychosis or current episode with psychosis of YMRS > 12 & HAM-D > 7 2. Patient on any Psychotropic drugs in the past 2 weeks 3. Patient on any other therapy (pharmacological, psychotherapy or somatic therapy) in the current episode 4. Patients diagnosed with other unstable medical (Hypothyroidism, Diabetes inscipidus, Myasthenia gravis, Chronic heart disease, Kidney disease, Hepatic failure, Pancreatitis, Bleeding disorders), neurological (Hyperammonemic encephalopathy, epilepsy) or surgical disorders 5. Patients who were unresponsive to either lithium or divalproex sodium in the past episodes 6. Patients who have received ECT in past 3 months 7. History of intolerance to either lithium or divalproex sodium because of the side effects in the past episodes 8. Pregnant or Breastfeeding Females 9. Substance dependence (except nicotine/ caffeine) in past six months

Design outcomes

Primary

Measure	Time frame
To determine the correlation between QEEG parameters at baseline and treatment response to Lithium and Divalproex sodium in bipolar affective disorder patientsTimepoint: 6 weeks	—

Secondary

Measure	Time frame
To determine the correlation between QEEG parameters at baseline and treatment response to Lithium and Divalproex sodium in bipolar affective disorder patientsTimepoint: 6 weeks	—

Countries

India

Contacts

Public ContactDr Priti Arun

Government medical college and hospital sector 32 chandigarh

drpritiarun@gmail.com9646121612

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026