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A randomized trial to compare the efficacy of dexamethasone and dexmedetomidine as adjuvants to 0.5% Ropivacaine in Adductor Canal Block for postoperative pain relief

Comparative evaluation of dexamethasone and dexmedetomidine as an adjuvant to 0.5% ropivacaine in Adductor Canal Block in terms of use of rescue analgesia for Anterior Cruciate Ligament Reconstruction surgeries: a randomized trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/02/023505
Enrollment
68
Registered
2020-02-21
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S833- Tear of articular cartilage of knee, current

Interventions

Intervention1: 4 mg Dexamethasone added to 0.5% Ropivacaine in single shot Adductor Canal Block: 17 ml of a solution including 15 ml of 0.5% Ropivacaine and 4 mg Dexamethasone and 1 ml normal saline t

Sponsors

Department of Anaesthesia and Intensive care Government Medical College and Hospital Chandigarh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age between 18 to 60 years of either sex. 2. American Society of Anaesthesiologist (ASA) physical status I and II of either sex. 3. BMI 20 to 30 kg/m2 4. Patients scheduled for ACL reconstruction surgery.

Exclusion criteria

Exclusion criteria: 1. Patientâ??s inability to understand VAS. 2. Patients with coagulopathy and bleeding disorders. 3. Pre-existing peripheral neuropathy. 4. Patients having history of substance abuse. 5. Pre-existing local infection at the site of block. 6. Pregnant and lactating women. 7.Contraindication to study drugs: Paracetamol, Diclofenac, Dexamethasone, Dexmedetomidine, Ropivacaine. 8. Patients having hemodynamic instability, hypotension, bradycardia, hepatic dysfunction. 9. Patients on regular chronic pain management drugs for the last three months.

Design outcomes

Primary

MeasureTime frame
To compare the time to first rescue analgesia in patients receiving ACB with dexamethasone and dexmedetomidine as adjuvants to 0.5% ropivacaine following ACL surgery.Timepoint: Immediately after the block then 5,10, 15 ,60 minutes followed by 2, 4, 6, 8,12 and at 24-hour interval—

Secondary

MeasureTime frame
Quadriceps StrengthTimepoint: 12- and 24-hours after administering the block.;Ramsay Sedation ScoreTimepoint: Immediately after block then 5, 10, 15, 60 minutes and followed by 2, 4, 6, 8, 12- and 24-hours interval.;Range of movement at knee jointTimepoint: 12- and 24-hours after administering the block.;Timed up and go testTimepoint: 24 hours postoperatively;Total analgesic consumption, nausea, vomiting or any other complaint along with sedation score, hemodynamic variables; BP, PR, RR, VAS at rest and on movementTimepoint: Immediately after block then 5,10, 15 ,60 minutes followed by 2, 4, 6, 8,12 and at 24-hour interval.—

Countries

India

Contacts

Public ContactDr Amanat Kang

Government Medical College and Hospital,Sector-32, Chandigarh

dpkthapa@gmail.com9646121524

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026