Health Condition 1: A180- Tuberculosis of bones and joints
Conditions
Interventions
Intervention1: Image guided biopsy from the affected vertebra using 8G needle: After thorough pre-procedural evaluation and preparation, patient will be made to lie in prone position on the table of
Sponsors
Dr Deep N Srivastava
Eligibility
Inclusion criteria
Inclusion criteria: Patients suspected to have TB spondylitis clinically, biochemically and radiologically and are treatment naive will be included in the trial. However patients who are subsequently found to have no evidence of tubercular infection on biopsy and further show no response to empirical ATT 1 month after the treatment will be excluded from the study.
Exclusion criteria
Exclusion criteria: Patients younger than 18 years of age, those not willing to give consent for the procedure and those having underlying bleeding. diathesis will be excluded from the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Histopathological and microbiological evaluation of biopsy sample. Histopathological findings(Present or Absent): 1.Granulomas/Giant cell 2.Necrosis 3.AFB positivity 4.Chronic Inflammation 5.Fibrosis 6.Osteonecrosis Microbiological studies: (Present/Absent) 1.GeneXpert 2.Culture All patients will receive ATT and response would be assessed after 4 weeks and 8 weeks using clinical, biochemical and radiological parameters.Timepoint: Baseline (within 7 days of acquiring biopsy)- Histopathology and microbiogical findings At 4 weeks-Clinical response At 8 weeks-Clinical response and MRI | — |
Secondary
| Measure | Time frame |
|---|---|
| All patients will receive ATT and response would be assessed after 1 month in form of: 1. Clinical (Pain, Fever, Weight gain, Appetite) 2. Biochemical (ESR, CRP) 3. Radiological (MRI)Timepoint: After 1 month of ATT, the clinical, biochemical and radiological assessment would be done | — |
Countries
India
Contacts
Public ContactDr Piyush Aggarwal
All India Institute of Medical sciences
Outcome results
None listed