COMPARISON OF TWO METHODS FOR WEANING A PATIENT FROM MECHANICAL VENTILATOR.

Comparison of Pressure support ventilation and T-piece ventilation during spontaneous breathing trials on successful extubation among patients on mechanical ventilation.

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/02/023466

Enrollment

160

Registered

2020-02-20

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G988- Other disorders of nervous system Health Condition 2: T449- Poisoning by, adverse effect of and underdosing of other and unspecified drugs primarily affecting the autonomic nervous system Health Condition 3: J969- Respiratory failure, unspecified Health Condition 4: I999- Unspecified disorder of circulatory system

Interventions

Intervention1: Pressure support spontaneous breathing trial with 8 cm H2O pressure: Pressure support ventilation is a mode of spontaneous breathing trial used during weaning trials in patients on mech

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients aged 18 years or older. 2.Patients undergoing mechanical ventilation for atleast 24 hours considered eligible for weaning by the following weaning criteria: A.Patient who are alert and co-operative. B.The resolution or improvement of the condition leading to intubation. C.Hemodynamical stability, defined as systolic blood pressure between 90 and 160 mmHg and heart rate less than 140/min without vasopressors or with low doses of vasopressors. D.Glasgow coma scale of 8 or greater. E.Respiratory stability, defined as oxygen saturation > 90% with FiO2 5mL/kg, PF ratio > 200. F.Non-copious secretions ( G.Diaphragmatic thickness fraction > 28. H.Rapid shallow breathing index I.Patients in spontaneous intermittent mandatory ventilation (SIMV) mode with a pressure support of 8.

Exclusion criteria

Exclusion criteria: 1.Pregnant women. 2.Patients with diaphragm paralysis. 3.Patients with neuromuscular disorders. 4.Patients on tracheostomy.

Design outcomes

Primary

Measure	Time frame
To compare pressure support ventilation and T-piece ventilation in providing successful extubation among mechanically ventilated patients.Timepoint: 3 days	—

Secondary

Measure	Time frame
1.To determine the rate of successful extubation. 2.To determine the rate of weaning failure 3.To estimate the 28-day mortality rate.Timepoint: 28 days	—

Countries

India

Contacts

Public ContactJohnson

PONDICHERRY INSTITUTE OF MEDICAL SCIENCES

kurien123@gmail.com9790014548

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026