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The effectiveness of a single dose of oral dexamethasone in treating an acute exacerbation of asthma when compared to three days course of oral prednisolone - a randomised controlled trial

Single dose oral dexamethasone versus multi dose prednisolone for acute exacerbations of asthma in children - a randomised controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/02/023435
Enrollment
216
Registered
2020-02-19
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J459- Other and unspecified asthma

Interventions

Intervention1: Nil: Nil Control Intervention1: Dexamethasone: Comparison of single dose oral dexamethasone at 0.6 mg per kg vs oral prednisolone for 3days at 1 mg per kg per day in the treatment of ac

Sponsors

none
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Known asthmatic children aged 2 to 12 years who present to the general medical department and pulmonology department with an acute asthma exacerbation.

Exclusion criteria

Exclusion criteria: 1.Reported use of oral corticosteroids in the 4 weeks before the current episode; 2. history of intubation; 3.concurrent stridor; 4.Pediatric Respiratory Assessment Measure (PRAM) score more than 8 (life threatening asthma & near fatal asthma) 5.chronic respiratory disease or cardiac disease

Design outcomes

Primary

MeasureTime frame
To compare whether a single dose of oral dexamethasone is superior to three days of oral prednisolone in the management of asthma exacerbations in childrenTimepoint: Assessment of participants from the time of admission for the enitre period of hospital stay, every 8th hourly using PRAM score.

Secondary

MeasureTime frame
Better patient complianceTimepoint: Time of admission to the time of discharge

Countries

India

Contacts

Public ContactDr S Kalpana

Institute of Child Health and Hospital for Children

drskalpana@yahoo.co.in9840720234

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026