Compare the effects of two drugs namely Magnesium and Rocuronium during intubation in general anesthesia

A double blinded randomized controlled comparative study between the effects of rocuronium priming and combination of rocuronium priming with magnesium pretreatment on intubating time and intubating conditions - MAGROC

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/02/023399

Enrollment

100

Registered

2020-02-17

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Z00-Z99- Factors influencing health status and contact with health services

Interventions

Intervention1: Magnesium sulphate priming: Comparison of intubation time and conditions with Magnesium sulphate priming with rocuronium Intervention2: Magnesium pretreatment with Rocuronium priming an

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status 1 & 2 BMI 18.5 - 24.9 kgm2 Mallampatti grade 1 & 2 Elective surgery under general anesthesia

Exclusion criteria

Exclusion criteria: patients with neuromuscular disease renal or hepatic insufficeincy allery to study drugs drugs that influence neuromuscular function breast feeding mothers or pregnancy anticipated difficult airway

Design outcomes

Primary

Measure	Time frame
1.Intubation conditions- which are assessed as excellent, good and poor using variables such as relaxation of jaw, resistance to blade insertion, position of vocal cords, and reaction to intubation 2. Duration of intubation is assessed as return of neromuscular blockade as TOF of twoTimepoint: Baseline single twitch, TOF at 170seconds after priming dose of Rocuronium, TOF at the end of the procedure before giving reversal agent	—

Measure

Time frame

1.Intubation conditions- which are assessed as excellent, good and poor using variables such as relaxation of jaw, resistance to blade insertion, position of vocal cords, and reaction to intubation 2. Duration of intubation is assessed as return of neromuscular blockade as TOF of twoTimepoint: Baseline single twitch, TOF at 170seconds after priming dose of Rocuronium, TOF at the end of the procedure before giving reversal agent

—

Secondary

Measure	Time frame
To compare the dosage of Rocuronium required in magnesium pretreatmentTimepoint: 1. Total dose of Rocuronium used in mgs 2. Duration of muscle relaxation attained 3. Dosage of sedatives and analgesics required in the postoperative period	—

Countries

India

Contacts

Public ContactDr CKSwetha ramani

SRM Medical college hospital & Research centre

swemohan@gmail.com09840045948

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026