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Comparing the ability to detect severe infection using existing blood test and new blood test in critically ill patients

Comparing the Diagnostic Accuracy of Presepsin and Procalcitonin for Sepsis in Critically Ill Patients: A Prospective Observational Study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2020/02/023337
Enrollment
40
Registered
2020-02-14
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A499- Bacterial infection, unspecified Health Condition 2: A418- Other specified sepsis Health Condition 3: A408- Other streptococcal sepsis Health Condition 4: A414- Sepsis due to anaerobes Health Condition 5: A413- Sepsis due to Hemophilus influenzae Health Condition 6: A415- Sepsis due to other Gram-negativeorganisms Health Condition 7: A411- Sepsis due to other specified staphylococcus Health Condition 8: A410- Sepsis due to Staphylococcus aureus Health Condition 9: A403-

Interventions

Control Intervention1: Nil: Nil

Sponsors

All India Institute of Medical Sciences Jodhpur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients aged >18 years 2. Patients having clinical features suggestive of sepsis as defined by Sepsis-3 definition (2016) at the time of ICU admission

Exclusion criteria

Exclusion criteria: 1.The patient/relatives who refused to give Informed consent 2.Age less than 18 years 3.Expired within 7 days of collection of 1st sample 4.Patients with terminal stage of disease (malignant cancer of any type, acquired immunodeficiency syndrome, end-stage liver or renal disease). 5.HIV/HBsAg/HCV. 6.Autoimmune disorders/Metabolic diseases 7.On long term steroids/ Immunosuppressants/ Chemotherapy

Design outcomes

Primary

MeasureTime frame
To evaluate sensitivity and specificity of presepsin and procalcitonin for detection of sepsis Timepoint: Within 24 hours of presentation—

Secondary

MeasureTime frame
1.Ability of presepsin to prognosticate the multi-organ failure in critically ill patients as assessed by SOFA scores. 2.To establish presepsin as a predictor of outcome of Sepsis in terms of 28 daysâ?? mortality. 3.To compare presepsin vs procalcitonin as a predictor of outcome of Sepsis in terms of 28 daysâ?? mortality. Timepoint: 1.Within 24 hours of presentation 2.28 days from the time of presentation 3.28 days from the time of presentation—

Countries

India

Contacts

Public ContactDr Shipra Roy

All India Institute of Medical Sciences, Jodhpur

drnikhilkothari@gmail.com8003996948

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026