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Clinical trial to study the effect of modulating blood flow to liver graft in cases of portal hyperperfusion in living donor liver transplantation

Graft Inflow Modulation for Portal Hyper-perfusion in Live Donor Liver Transplantation: a Randomized Pilot Study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/02/023273
Enrollment
42
Registered
2020-02-12
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K746- Other and unspecified cirrhosis ofliver

Interventions

Intervention1: Splenic artery ligation: For Graft inflow modulation, Splenic artery will be ligated just after takeoff from coeliac trunk at the level of body of pancreas. Control Intervention1: No li

Sponsors

Institute of Liver and Biliary Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Portal Venous Pressure (PVP) > 15 mm Hg after reperfusion or Portal venous flow (PVF) > 250 ml/min/100 gr of liver after reperfusion or HVPG > 15 mm Hg after reperfusion

Exclusion criteria

Exclusion criteria: Significant peripancreatic collaterals preventing safe access to splenic artery Acute Liver Failure as an indication for transplant ABO incompatible transplants Pediatric transplants Refusal to participate in the study

Design outcomes

Primary

MeasureTime frame
To compare the incidence of early graft dysfunction and time to normalization of bilirubin, INR and ascites between the two groups (who undergo graft inflow modulation and those who do not) - Group A â?? those who undergo GIM - Group B â?? those who do not undergo GIM Timepoint: Till patient is dicharged from hospital

Secondary

MeasureTime frame
- To compare Morbidity and Mortality - To compare ICU and total hospital stay Timepoint: Till patient is dicharged from hospital

Countries

India

Contacts

Public ContactDr Viniyendra Pamecha

Institute of Liver and Biliary Sciences

viniyendra@yahoo.co.uk9540946803

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026