Health Condition 1: G20- Parkinsons disease
Conditions
Interventions
Intervention1: Indian Music Rhythm Perception and Production based Intervention: It is a three month long (48 session) Indian Music Rhythm based Neuropsychological intervention.
Control Intervention1:
Sponsors
Wellcome Trust India Alliance DBT Intermediate CPHI Fellowship
Eligibility
Inclusion criteria
Inclusion criteria: For PD group 1. Diagnosis of PD according to UK Brain Bank diagnostic criteria. 2. Patients from both gender 3. Age range 40 to 65 years. 4. Right Handedness- determined by Edinburgh Handedness Inventory39 5. With formal education of 7 years with fluency in Hindi , English or Kannada 6. Patients with Hoehn and Yahr stage40 1 to 2.5. 7. Normal or corrected vision and hearing. 8. Patients who are adhering to medication /pharmacological treatment and those who have been on stable medication 2-month before recruitment. For Healty Control group (HC) group 1. Right Handedness- determined by Edinburgh Handedness Inventory39 2. HMSE score (score 24 or above) 3. Age range â?? 40 to 65 years 4. Both gender 5. Adequate hearing and visual ability/ corrected vision and audition 6. With formal education of 7 years with fluency in Hindi, English or Kannada and Right handedness. 7. Fluent in speaking in English/Hindi/Kannada
Exclusion criteria
Exclusion criteria: For PD group 1. Cognitive impairment assessed by Hindi Mental status examination41 (HMSE score less than 24 ) 2. Patient undergoing or those who have undergone any other form of cognitive remediation or any music based therapy in the last 6-months. 3. Any other psychiatric and neurological conditions other than PD. 4. Neurologic or medical disorders interfering with gait or cognition such as previous stroke, head injury, brain tumour, rheumatologic or orthopaedic disorder etc 5. Patients with severe sensory deficits (visual /auditory) which will affect participation in intervention study. 6. Patients with severe level of depression or anxiety as assessed by HADS 42 or clinically evaluated psychotic - severe enough to hinder their participation in intervention as assessed by clinical interview with patient and care giver. 7. Any contraindications for undergoing magnetic resonance imaging For HC group 1. Formal training more than two years in any form of music 2. History of any Neurological/Psychiatric/Neurosurgical condition. Score of 12 or more Kesslerâ??s 6 Screening Scale (K6)43
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Phase 1: Music perception and Emotion perception Phase 2: fMRI-neural correlates and changes in functional connectivity Music and rhythm perception, emotion perception, quality of sleep, levels of depression, anxiety and quality of lifeTimepoint: Phase 1: Soon after the neuropsychological evaluation Phase 2: Three time points At baseline, 3 month and 6 month follow-up | — |
Primary
| Measure | Time frame |
|---|---|
| Phase 1- Neurocognitive functions and rhythm perception functional connectivity via resting state fMRI Phase 2:working memory index) and motor functions (UPDRS-III motor functions scoresTimepoint: Phase 1- Soon after the neuropsychological evaluation and MRI scan functional connectivity via resting state fMRI Phase 2:At baseline, post 3 month intervention and 6 month follow up period | — |
Countries
India
Contacts
Public ContactDr Shantala Hegde
National Institute of Mental Health and Neuro Sciences
Outcome results
None listed