Health Condition 1: N178- Other acute kidney failure
Conditions
Interventions
Intervention1: Spironolactone: Spironolactone will be started at a dose of 25 mg once daily and increased to 50 mg once daily at 4 weeks,provided the serum potassium is no more than 4.5 mmol/l.The do
Sponsors
Government of West Bengal
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients of Acute Kidney Disease, defined as patients with serum creatinine >1.5 times the baseline or egfr
Exclusion criteria
Exclusion criteria: Patients unable to provide informed or surrogate consent Patients with serum potassium >4.5 Females who are pregnant ,lactating or unwilling to use contraception. Patients who are hypotensive with BP Patients with any absolute or relative contraindication for doing renal biopsy. Patients with acute GN diagnosed clinically or by biopsy. Patients with Clinically significant urinary tract obstruction , confirmed by imaging. Patients with history of allergy to spironolactone. Patients with history of any malignancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage change in estimated glomerular filtration rate in the study group compared to control group. Timepoint: Percentage change in estimated glomerular filtration rate in the study group compared to control group at 0 and 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in mean blood pressure and antihypertensive requirement between baseline and 6 months. Timepoint: 0 and 6 months;Percentage Change in proteinuria as compared to baseline. Timepoint: 0 and 6 months;Percentage Change in renal fibrosis as measured by trichrome staining of renal biopsy tissues scored by two pathologists independently.Timepoint: 0 and 6 months;Rate of serious adverse events (resulting in death or nonelective hospitalization)Timepoint: 6 months | — |
Countries
India
Contacts
Public ContactSyed Mubashir Nissar
Institute of Post Graduate Medical Education and Research
Outcome results
None listed