Health Condition 1: G931- Anoxic brain damage, not elsewhereclassified
Conditions
Interventions
Intervention1: targeted temperature management, remote ischemic conditioning, fentanyl: each arm will receive either of targeted temperature management, targeted temperatrue management and RIC, target
Sponsors
Department of Biotechnology India
Eligibility
Inclusion criteria
Inclusion criteria: 1.Both male and female patients of age >18 years 2.Successful resuscitation of in-hospital or out-hospital cardiac arrest of any cause 3.Glasgow coma scale of 8 or less at any time after restoration of spontaneous circulation 4.Prognosis after Resuscitation (PAR) score of 5.Presenting within first 6 hours of return of spontaneous circulation
Exclusion criteria
Exclusion criteria: 1.Pregnancy 2.Refractory Hypotension (Systolic blood pressure 3.Severe cardiac comorbidity 4.In-hospital comorbidities precluding the patient from hypothermia 5.On-going bleeding 6.Preexisting coma of other cause 7.Major surgery within last 14 days 8.Major head trauma 9.Family wishes goals of care as do not resuscitate 10.Traumatic arrest 11.Severe sepsis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is serum neuron specific enolase (NSE) at 72 hours after return of circulation.Timepoint: The primary outcome is serum neuron specific enolase (NSE) at 72 hours after return of circulation. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary clinical outcome measures are mortality at 6 months, neurological disability at 6 months as assessed by modified Rankin scale, and cognitive dysfunction as assessed by Montreal cognitive assessment. The secondary imaging outcome measure include volume ischemic lesion at 1 week and cerebral atrophy at 6months assessed using MRI brain FLAIR sequence and T1 W MPRAGE sequence respectively.Timepoint: 6months | — |
Countries
India
Contacts
Public ContactDr Rajeshwar
Christian Medical College and Hospital
Outcome results
None listed