Comparing the the level of a growth promoting factor(TGF beta 1) in the gum fluid of bone defects treated using a membrane derived from animal tissues and a membrane derived from human fetal sac

Comparison of the level of transforming growth factor beta 1 in the GCF of periodontal defects treated with collagen membrane and amniotic membrane-A Randomized control trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/01/023036

Enrollment

Registered

2020-01-30

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A00-B99- Certain infectious and parasitic diseases

Interventions

Intervention1: Amniotic Membrane: The amniotic membrane encases the amniotic fluid and fetus.The matrix of human amniotic membrane contains abundant growth factors.It is procured from Tata memorial re

Eligibility

Inclusion criteria

Inclusion criteria: Patients with a probing depth of more than 6mm and evidence of vertical bone loss in the first or second molar region(two walled defect)

Exclusion criteria

Exclusion criteria: smokers, pregnant and lactating women, medically compromised patients

Design outcomes

Primary

Measure	Time frame
Increase in the level of TGF beta 1 in the defect treated with amniotic membrane.Timepoint: baseline one week four weeks 12 weeks 24 weeks	—

Secondary

Measure	Time frame
reduction in clinical parameters and increase in bone fillTimepoint: baseline and 24 weeks	—

Countries

India

Contacts

Public ContactMeghna sreekumar

Amrita School Of Dentistry

angelfenol@gmail.com9037326910

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026