Health Condition 1: K80-K87- Disorders of gallbladder, biliary tract and pancreas
Conditions
Interventions
Intervention1: Plasma exchange therapy: The high volume plasma exchange (HVPE) procedure will be performed at the bedside of the patient enrolled in the study in the intensive care unit (ICU) under th
Sponsors
Department of Gastroenterology all India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Patients will be included if they meet the following inclusion criteria: 1. Patients with AP diagnosed as per revised Atlanta classification22 2. Patients with two organ failures each >= grade 2 or single organ failure > grade 2 severity at presentation. 3. Hospitalization within 7 days of onset of pancreatitis
Exclusion criteria
Exclusion criteria: 1. Age 75 years 2. Patients admitted after 7 days of onset of AP 3. Patients with hypotension requiring inotropes 4. Patients with evidence of chronic pancreatitis 5. Refusal to give consent 6. Patients with any major comorbid condition such as chronic kidney disease, congestive heart failure or respiratory illnesses.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Any adverse event will be the primary outcome. Timepoint: 4 week | — |
Secondary
| Measure | Time frame |
|---|---|
| The improvement in organ failure and survival at 4 weeks will be the secondary outcome.Timepoint: 4 week | — |
Countries
India
Contacts
Public ContactSoumya Jagannath Mahapatra
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed