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Evaluation of toothpaste containing novel antimicrobial agent for controlling plaque and gum diseases

Comparative evaluation of chlorhexidine di-undecylenate, triclosan and herbal tooth paste in controlling plaque and gingivitis

Status
Active, not recruiting
Phases
Phase 1Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/01/023024
Enrollment
88
Registered
2020-01-28
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: tooth paste containing chlorhexidine di undecylinate-0.1%: study or experimental group consist of 44 subjects. A Tube consists of 100 mg of toothpaste containing 0.1mg chlorhexidine und

Sponsors

Salicylates and chemicals pvt ltd
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Subjects between the ages 18 and 50(inclusive);and in generally good health. 2.Subjects who are available for the entire study period . 3.Subjects had to possess atleast 20 uncovered permanent natural teeth (excluding thrid molars) 4.Mean plaque index score of atleast 1.5 determined by the turesky modification of the Quigley -Hein plaque index will be enrolled in the study. 5. mean gingival index score of 1 determined by modified loe and sillness index

Exclusion criteria

Exclusion criteria: If they had advanced periodontal disease (purulent exudate,tooth mobility, and /or extensive loss of periodontal attachment or alveolar bone. 2. Five or more decayed carious lesions requiring immediate restorative treatment. 3.Tumor(s) of the soft or hard oral tissues of oral cavity ,or presence of partial removable dentures or presence of orthodontic bands 4.Subjects on any prescribed medications that could interfere with the study outcome or used antibiotics within 1 month prior to the study 5. If they started taking then during the course of the study or received a dental prophylaxis in the 2 weeks prior to the baseline examination . 6.Pregnant or lactating women ,individuals who are participating in any other clinical study ,or individuals who had participated in a study , or individuals with history of alcohol or drug abuse were not allowed to participate in the study 7. Subjects with the history of allergies to the taste products , or allergies to oralcare , / personal care consumer products or their ingredients ,or subjects with existing medical conditions which prohibits them from eating and drinking for periods up to 4 hours were also excluded from the study .

Design outcomes

Primary

MeasureTime frame
plaque and gingivitisTimepoint: baseline and eight weeks

Secondary

MeasureTime frame
staining on the tooth surface, altered taste sensationTimepoint: Every two weeks

Countries

India

Contacts

Public ContactParappa Sajjan

Mallareddy Institute of Dental sciences

drsajjan12@gmail.com7032801400

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026