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Skin graft harvest site healing with local application of Phenytoin drug

Effectiveness of topical phenytoin in split thickness skin graft donor site healing

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/01/023014
Enrollment
80
Registered
2020-01-28
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L762- Postprocedural hemorrhage of skinand subcutaneous tissue following a procedure

Interventions

Intervention1: Phenytoin dressing group: Split skin grafts donor sites of patients in the study group will be dressed with phenytoin suspension, and the dressing would be opened on post-operative day

Sponsors

Lok Nayak Hospital and associated MAMC
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients requiring split skin graft harvest for coverage of raw areas of varied etiology.

Exclusion criteria

Exclusion criteria: Co-morbidities like diabetes, hypertension, liver disease, kidney disease, cardiac disease, malignancy, malnourished patient (BMI 5% weight loss in last 3 months, reduced nutritional intake for last 5 days). Patients on oral Phenytoin for any systemic condition. Pregnancy and lactation.

Design outcomes

Primary

MeasureTime frame
Days to complete epithelization of donor siteTimepoint: 10th post-operative day for Study Group and 15th Post-operative day for Control Group patients.

Secondary

MeasureTime frame
Pain at the donor site (VAS scores) at 24, 48 and 72 hours post operatively. Any evidence of infection at the donor site. Timepoint: Pain at the donor site (VAS scores) at 24, 48 and 72 hours post operatively. Any evidence of infection at the donor site.

Countries

India

Contacts

Public ContactDr Parth Pratim Pasayat

Lok Nayak Hospital

drpsacademics@gmail.com09873617581

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026