Health Condition 1: A753- Typhus fever due to Rickettsia tsutsugamushi
Conditions
Interventions
Intervention1: Azithromycin: 10mg/kg/day for 5 days
Control Intervention1: Doxycycline: 2.2 mg/kg/ dose BD in children less than 40 kg and 100 mg BD in children more than 40 kg for 7 days
Sponsors
Director Principal
Eligibility
Inclusion criteria
Inclusion criteria: Children admitted in the hospital will be eligible for enrollment if they fulfill the following inclusion criteria: Children 6 months to 18 years suffering from acute febrile illness of 5 days or more and scrub typhus IgM serology positive by ELISA (cutoff optical density 0.5 or more)
Exclusion criteria
Exclusion criteria: Patients will be excluded from study if : 1. History of hypersensitivity to macrolides or tetracylines. 2. Indications of presence of a febrile illness unrelated to scrub typhus. 3. Patients who had ingested any agents with potential antirickettsial activity (e.g., rifampicin, chloramphenicol, macrolides, or tetracycline) within 48 hours prior to randomization. 4. Patient with heart disease. 5. Post randomization scrub IgM serology negative in case of critically sick patients who are randomized awaiting scrub serology.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Our primary outcome shall be the proportion of children achieving defervescence within 5 days of starting DX or AZ. Defervescence is defined as the interval between the time at which first dose of antibiotic is administered  and the time at which the axillary temperature falls below 37.8Ë?C and is maintained for 48 hours without antipyretics. Timepoint: defervescence within 5 days of starting DX or AZ. | — |
Secondary
| Measure | Time frame |
|---|---|
| Additionally participants will be assessed for hospitalization duration, time to defervescence, need for ventilation, inotropic support, blood transfusion, renal replacement therapy and any adverse event. Timepoint: day5,7, 1 month | — |
Countries
India
Contacts
Public ContactAnjali Sharma
Government Medical College and Hospital
Outcome results
None listed