Health Condition 1: G431- Migraine with aura Health Condition 2: G430- Migraine without aura
Conditions
Interventions
Intervention1: Amitriptyline: Tablet 5mg once daily for 2 weeks followed by 10mg once daily for next 10 weeks
Control Intervention1: Propranolol: Tablet 20mg twice daily for 2 weeks followed by 40mg t
Sponsors
Maulana azad Medical College
Eligibility
Inclusion criteria
Inclusion criteria: Patient with episodic migraine (4-14 migraine headache attacks per month) with/without aura
Exclusion criteria
Exclusion criteria: 1. Patients with a history of asthma, chronic obstructive pulmonary disease, atrioventricular conduction defects, bradycardia, peripheral vascular disease, uncontrolled diabetes mellitus, uncontrolled hypertension, glaucoma, seizure disorder, cardiac diseases. 2. Patients with severe depression and anxiety disorders or with 3-months previous history of antipsychotic, antidepressants or antianxiety medications. 3. Patients on any other prophylactic treatment for migraine. 4. Patients with known allergy to the study medications. 5. Patients with deranged routine baseline investigations. 6. Patients developing severe adverse drug reactions during the treatment. 7. Pregnant and nursing mothers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in frequency of migraine headache at the end of 3 monthsTimepoint: 4 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Proportion of patients having 50% reduction in migraine headache 2. Reduction in headache severity and headache induced disability 3. Number and dose of rescue medication taken. 4. Frequency and severity of adverse drug reactions. 5. Change in quality of life after treatment. 6. Cost effectiveness of propranolol versus amitriptyline.Timepoint: 4 months | — |
Countries
India
Contacts
Public ContactDr Nasra Banu
Maulana Azad Medical College
Outcome results
None listed