Health Condition 1: F32- Major depressive disorder, singleepisode
Conditions
Interventions
Intervention1: Vortioxetine: Started at a dose of 10 mg,may be incremented to 20 mg, by oral route once daily for 6 weeks
Intervention2: Vortioxetine and Escitalopram (Antidepressants): 70 cases of Ma
Sponsors
Government medical college
Eligibility
Inclusion criteria
Inclusion criteria: 1.First episode of major depressive disorder as per DSM-5. 2.Drug naÃ?¯ve 3.Giving informed consent for inclusion in study 4.Age group of 18 ââ?¬â?? 55 years 5.Educated up to at least 10th standard
Exclusion criteria
Exclusion criteria: 1.Any other co-morbid psychiatric illness 2.Patients with intellectual disability 3.Patients with co-morbid substance dependence excluding nicotine and caffeine 4.History of any chronic medical or surgical illness or any neurological disorder 5.Pregnant and lactating patients 6.Actively suicidal patients 7.Receiving Cognitive Enhancement Therapy, Cognitive Behavior Therapy or any psychological treatment in last 6 weeks 8.Receiving Electro Convulsive Therapy (ECT) in last 6 weeks 9.Any known hypersensitivity reaction to vortioxetine and escitalopram
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the perceived and objective cognitive deficits in patients with first episode of major depressive disorder receiving vortioxetine and escitalopram at baseline and at 6 weeks respectivelyTimepoint: At baseline and at the end of 6 weeks respectively | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the perceived and objective cognitive functions in treatment responders and treatment non respondersTimepoint: At the end of 6 weeks | — |
Countries
India
Contacts
Public ContactSahildeep Kaur
Government medical college and hospital,Sector 32
Outcome results
None listed