FindTrial
Sign In

Comparing two drugs for prevention of sore throat after laparoscopic surgery

To compare the effectiveness of dexmedetomidine versus combination of lignocaine and dexamethasone on postoperative sore throat in patients undergoing elective laparoscopic surgery in Trendelenburg position

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/01/022922
Enrollment
135
Registered
2020-01-23
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C679- Malignant neoplasm of bladder, unspecified

Interventions

Intervention1: Dexmedetomidine: 1 microgram/kg body weight diluted with normal saline to make 20 ml given over 10 mins starting 5 mins before intubation Intervention2: dexamethasone-lignocaine combina

Sponsors

Dr Divya Abhishek Kishore
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status I-III, Undergoing elective laparoscopic surgery in Trendelenburg position Requiring endotracheal intubation Duration of surgery >90minutes Expected to remain admitted in the hospital for >24hours.

Exclusion criteria

Exclusion criteria: Patients with preexisting sore throat/ hoarsen · ASA physical status IV · BMI > 30 · Vocal performer by occupation · Recent or recurrent respiratory tract infection ·Risk of postoperative aspiration (obesity, pregnancy ) · Pain medications, corticosteroids ; calcium channel blocker · 2nd and 3rd degree Heart block  · Allergy to Study drugs ·Anticipated difficult intubation(Mallampati grade >2, difficult mask ventilation requiring oral/nasal airway, Cormack and Lehane grade III-IV) Intubation attempt >1

Design outcomes

Primary

MeasureTime frame
Post operative sore throatTimepoint: 15min,1h,6h,12h,24h—

Secondary

MeasureTime frame
Post operative sore throat on swallowingTimepoint: 15min,1h,6h,12h,24h;Bloodstain over endotracheal tubeTimepoint: 30 sec post extubation;Percentage of glottic opening scoreTimepoint: 2 seconds before endotracheal intubation;Total morphine consumptionTimepoint: 24h after surgery—

Countries

India

Contacts

Public ContactDr Divya Abhishek Kishore

Rajiv Gandhi Cancer Institute and Research Centre

manojb8@gmail.com9968604220

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026