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Can we protect nerves that carry smell to the brain during brain surgery by measuring the electrical activity? A study to assess the feasibility of such a technique.

Olfactory evoked potential monitoring during neurosurgery to preserve the olfaction: A feasibility study

Status
Recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/01/022920
Enrollment
36
Registered
2020-01-23
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G978- Other intraoperative and postprocedural complications and disorders of nervous system

Interventions

Intervention1: Olfactory evoked potential monitoring: After induction of anesthesia using the standard techniques which are compatible with IONM, we will place, the stimulating electrical electrode

Sponsors

JIPMER Pondicherry
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All patients who are undergoing frontal craniotomy where retraction of the frontal lobe from the base of the brain is likely

Exclusion criteria

Exclusion criteria: Critically ill patients Emergency neurosurgical procedures where time cannot be spent to place electrodes Patients who have already known to have lost olfaction because of previous trauma or surgery or any other condition. Patients whose clinical status (such as those with impaired consciousness) preclude testing of olfaction before surgery

Design outcomes

Primary

MeasureTime frame
What is the percentage of patients in whom we can successfully measure intraoperative olfactory evoked potential during surgery? Timepoint: During the surgical procedure when the testing is going on. (Day one of the trial period)

Secondary

MeasureTime frame
What percentage of patients suffer olfactory damage in frontal craniotomies with and without monitoring. Timepoint: One assessment during surgery and clinical testing in the post operative period (usually within ten days of surgery)

Countries

India

Contacts

Public ContactGopalakrishnan Madhavan sasidharan

JIPMER

gopalakrishnanms@gmail.com919345141431

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026