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Comparison between two methods of providing oxygen in children with severe pneumonia

Nasal continuous positive airway pressure versus high flow humidified nasal cannula for oxygen therapy in children with severe pneumonia: A randomized controlled trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/01/022903
Enrollment
40
Registered
2020-01-21
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J22- Unspecified acute lower respiratory infection

Interventions

Intervention1: Nasal continuous positive airway pressure: Pressure at 6 to 8 cm water Control Intervention1: High flow humidified nasal cannula: Flow rate at 2L/kg/min

Sponsors

nil
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All children from 1 months to 59 month with severe pneumonia( modified WHO guildelines 2014) and hypoxemia and present in paediatric ICU; 1.Cough with/without fever with fast breathing and/or chest indrawing AND 2.Any 1 of the General Danger signs (lethargy, reduced level of consciousness , convulsion, not able to drink, persistent vomiting) AND 3.Hypoxaemia (SPO2

Exclusion criteria

Exclusion criteria: 1.Children requiring Mechanical Ventilation or intubation at presentation 2.Children already exposed to HFNC or CPAP before coming to PICU 3.Children with craniofacial abnormality or maxillofacial surgery (cleft palate, choanal atresia etc) 4.Children with air leak syndrome (pneumothorax, pneumomediastinum, subcutaneous emphysema) 5.Children with neuromuscular diseases 6.Known case of asthma or upper airway obstruction 7.Children with tracheostomy

Design outcomes

Primary

MeasureTime frame
Proportion of children developing Respiratory support Failure in CPAP and HFNC in first 72 hours.Timepoint: Monitoring would be done at baseline, hourly for the first 6 hours and then at 12, 18, 24, 36, 48 and 72 hr of initiating respiratory support—

Secondary

MeasureTime frame
Mean score of modified COMFORT score in both the groups.Timepoint: first 72 hour;Proportion of children developing adverse events/mortality in both the groupsTimepoint: hospital stay;Proportion of children requiring intubation or mechanical ventilation in both the groupsTimepoint: hospital stay;Total length of stay in PICU/hospital stay in both the groupsTimepoint: hospital stay—

Countries

India

Contacts

Public ContactDr Shikha Yadav

LHMC and Kalawati Saran Children Hospital

sguptabhu@gmail.com9779577087

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026