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Effect of a newer drug(magnesium sulfate)given in abdominal cavity at the end of operation for removal of gall bladder through endoscope for providing pain relief

Comparison of Intraperitoneal instillation of Bupivacaine versus Bupivacaine with Magnesium Sulfate for postoperative analgesia after laparoscopic cholecystectomy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/01/022900
Enrollment
60
Registered
2020-01-21
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: magnesium sulfate with bupivacaine: intraperitoneal instillation of magnesium sulfate in a dose of 50mg/kg along with bupivacaine 0.25% 30 ml Control Intervention1: bupivacaine: intrape

Sponsors

Medical CollegeVadodara
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients posted for elective laparoscopic cholecystectomy American Society of Anaesthesiologists physical status I,II and III Age from 18 to 65 years Either sex

Exclusion criteria

Exclusion criteria: Patient having allergy to study drug(MgSO4 or Bupivacaine) Patients with liver and Renal failure Patients with heart block Chronic alcoholism or drug abuse Patients receiving any sort of pain medication on chronic basis

Design outcomes

Primary

MeasureTime frame
To compare the analgesic efficacy and duration of pain relief by measuring following parameters in the postoperative period Visual analog score(VAS) Time to first requirement of rescue analgesia Number of rescue analgesics required in first 24 hours Timepoint: 24 hours

Secondary

MeasureTime frame
To see the effects of study drugs on vital parameters To observe Side effects if any like nausea, vomiting, hypotension, bradycardia, respiratory depression and sedation. Timepoint: 24 hours

Countries

India

Contacts

Public ContactDamor Chirag

Government medical college Vadodara

dr.darshna1968@yahoo.com9925013155

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026