Health Condition 1: I959- Hypotension, unspecified
Conditions
Interventions
Intervention1: Vitamin C: In addition to standard protocol for management of septic shock, Vitamin C will be administered at a dose of 25 mg/kg at 6 hourly intervals.
Control Intervention1: Placebo: I
Sponsors
All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. Children 2 months to = 17 years of age admitted to the ICU with a diagnosis of septic shock
Exclusion criteria
Exclusion criteria: 1. Children with chronic kidney disease. 2. Children with fulminant myocarditis 3. Children with dengue shock syndrome 4. Children on Vitamin C or Thiamine or steroid supplements 5. Children on anticancer drugs, drugs for autoimmune diseases 6. Children with G6PD deficiency 7. Children on iron supplements for iron deficiency anemia (can exaggerate iron absorption, iron overload and tissue damage) 8. Post-arrest shock and cardiac dysfunction 9. Moribund patients in who anticipated survival is
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Change in P-SOFA score at 72 hours from P-SOFA scores at the time of enrollment (referred to as ‘0’ hour score)Timepoint: 1. 72 hours of enrollment | — |
Secondary
| Measure | Time frame |
|---|---|
| MortalityTimepoint: 28 day mortality | — |
Countries
India
Contacts
Public ContactJhuma Sankar
All India Institute of Medical Sciences
Outcome results
None listed