Health Condition 1: I251- Atherosclerotic heart disease of native coronary artery
Conditions
Interventions
Intervention1: Milrinone: Dose: 0.375 microgram per kilogram body weight per minute
Frequency: As continuous infusion through infusion Pump
Route: Intravenous
Duration: Intraoperative period, Immedia
Sponsors
GB pant institute of postgraduate medical education and research
Eligibility
Inclusion criteria
Inclusion criteria: 1. Adult patients posted for elective OPCAB 2. Adult patients with left ventricular dysfunction with ejection fraction less than or equal to 35%
Exclusion criteria
Exclusion criteria: 1. Patients having EF more than 35% 2. Patients simultaneously operated for any other surgery along with OPCAB 3. Patients having deranged renal functions 4. Patients having deranged hepatic function 5. Patients having thrombocytopenia or any known bleeding disorders 6. Patients having clinically significant arrhythmia 7. Patients having obstructive airway or lung parenchymal disease 8. Patients requiring dose of milrinone >0.5 μgm/kg/min 9. Patients requiring any other inotropic agents intraoperatively 10.Patients requiring conversion from OPCAB to ON PUMP CAB
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiac IndexTimepoint: Twenty minutes after starting infusion of drug/placebo followed by after every ten minutes of stabilizer application | — |
Secondary
| Measure | Time frame |
|---|---|
| systemic vascular resistance index, pulmonary venous resistance index, stroke volume indexTimepoint: Twenty minutes after starting infusion of drug/placebo followed by after every ten minutes of stabilizer application | — |
Countries
India
Contacts
Public ContactDr Manish Kumar
GB pant institute of postgraduate medical education and research
Outcome results
None listed