Health Condition 1: A183- Tuberculosis of intestines, peritoneum and mesenteric glands
Conditions
Interventions
Intervention1: Drug: Prednisolone 40 mg for 4 weeks and then 30 mg for 2 weeks,20 mg for 1 week and 10 mg for 1 week
Control Intervention1: Placebo: Placebo tablets to be given for total 8 weeks
Sponsors
G B Pant Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1.Proven ileo-colonic tuberculosis and 2.Proven stricture with radiographic and/or endoscopic evidence and 3. Symptomatic for stricture
Exclusion criteria
Exclusion criteria: 1.Age 75 years 2.Coexisting HIV, Malignancy, Pregnancy 3.Past history of abdominal tuberculosis 4. Past abdominal surgery 5. Coexisting inflammatory bowel disease 6.Contraindications for steroid use like osteoporosis, glaucoma, uncontrolled diabetes, uncontrolled ongoing sepsis, excess fluid retention like congestive heart failure, renal failure, cirrhosis with ascites 7. Post-surgical diagnosis of tuberculosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| improvement in stricture either by colonoscopy or by CECT enterographyTimepoint: Outcome assessed after 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Symptoms improvement in form of Pain reduction, Weight gain 2 No of hospital admissions for pain 3. requirement of surgery 4.MortalityTimepoint: At 2months and at 6 months | — |
Countries
India
Contacts
Public ContactAshok Dalal
G B Pant Hospital
Outcome results
None listed