A study to compare effect of two medicines (e.g. Dexmedetomedine and Lignocaine) on pressure inside brain,blood pressure and heart rate after removal of throat secretion (tracheal suction)in head injury patient.

Compare the efficacy of Dexmedetomidine versus Lignocaine on optic nerve sheath diameter and systemic pressure dynamics after tracheal suctioning in patients with severe traumatic brain injury: A randomized control trial

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/01/022696

Enrollment

Registered

2020-01-10

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G528- Disorders of other specified cranial nerves

Interventions

Intervention1: Inj. Dexmedetomidine: 0.4 mcg/kg + normal saline (total 20 ml solution) intravenous via infusion pump over 15 minutes, single dose . Control Intervention1: Inj. Lignocaine: 2 mg/kg + no

Eligibility

Inclusion criteria

Inclusion criteria: Patients 18 to 65 years of age with severe traumatic brain injury admitted to ICU undergoing mechanical ventilation and having optic nerve sheath diameter lessthan or equalto 5.8mm(aproximately 20mmHg of ICP) and SBP greaterthan or equal to 90 mm Hg

Exclusion criteria

Exclusion criteria: Heart rate less than 45 , any chest injury, presence of haemothorax, pneumothorax, or a chest drainage tube, patient on dexmedetomidine infusion and patients who deny consent.

Design outcomes

Primary

Measure	Time frame
To compare the mean of optic nerve sheath diameter between dexmedetomedine and lignocaine group before and after tracheal suctioning in severe traumatic brain injury patients.Timepoint: 15 minutes	—

Secondary

Measure	Time frame
To compare various systemic pressure dynamics(mean atrial pressure, heart rate) between dexmedetomedine and lignocaine group before and after tracheal suctioning in severe traumatic brain injury patients.Timepoint: 15 minutes	—

Countries

India

Contacts

Public ContactDr Diwakar Thapa

Maharashtra University of Health Sciences

drnsethi@yahoo.co.in9873029832

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026