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Effect of different anesthetic techniques on inflammatory markers in patients undergoing major orthopedic trauma surgery

Perioperative inflammatory cytokines alteration and neutrophil extracellular trap formation with various anesthetic techniques in patients undergoing major orthopedic trauma surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/01/022682
Enrollment
70
Registered
2020-01-10
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S723- Fracture of shaft of femur

Interventions

Intervention1: General and regional anesthesia: Anesthetic Technique: Patients will be assigned to different anesthetic technique by computer generated randomization. Pre-anesthetic checkup will be d
night prior surgery as pre-medication. Group A: General Anesthesia Group A patients will receive balanced general anaesthesia comprising of fentanyl (2 mcg/kg) + propofol (2 mg/kg) followed by endo
drug used will be 0.5 % bupivacaine (heavy) 2.5- 3 mL. Once the level recedes below T 10, test dose of 3 mL 2% lignocaine adrenaline (1:200,000) will be given through epidural catheter. If test dose i

Sponsors

AIIMS
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Male or female arriving in OT for pelvic-acetabular injury and fracture shaft femur. 2. More than18- 60 years of age. 3. ASA Grade I/II patients i.e. with minimal risk of anesthesia as per standard practices.

Exclusion criteria

Exclusion criteria: 1. A Signs of infection present. 2. History of being operated within 3 months for any ailment. 3. Any allergy to anesthetic/ local anesthetic drugs. 4. Redo surgery. 5. Patient on immunosuppressant therapy. 6. History of inflammatory disorder. 7. Patients with difficult airway requiring fiber-optic intubation. 8. Contraindication to regional anesthesia i.e.platelet count 1.5 9. Spine pathology present.

Design outcomes

Primary

MeasureTime frame
Influence of anesthetic technique on neutrophil extracellular trap & histone and stablish the diagnostic ability of NETs and Histone to early diagnosis of SIRS in major orthopedic trauma patients.Timepoint: 5 years—

Secondary

MeasureTime frame
1.Quantification of NETs, histone and pro/anti-inflammatory cytokines at consecutive time points after major orthopedic surgery. 2. Optimal timing for nonlife-saving surgical interventions after trauma. 3. Damaged tissue healing and repair. 4. Second hit related MOF. 5. Hospital stay.Timepoint: 5 years—

Countries

India

Contacts

Public ContactPallavi Tiwari

All India Institute of Medical Sciences, New Delhi

drbabitagupta@hotmail.com9868397815

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026