Health Condition 1: S324- Fracture of acetabulum
Conditions
Interventions
Intervention1: Regional Anesthesia and General Anesthesia: General Anesthesia Group
These patients will receive balanced general anaesthesia comprising of fentanyl (2 mcg/kg) + Propofol (2 mg/kg) foll
drug used will be 0.5 % bupivacaine (heavy) 2.5- 3 mL. Once the level recedes below T 10, test dose of 3 mL 2% lignocaine adrenaline (1: 200,000) will be given through epidural catheter. If test dose
Sponsors
AIIMS Intramural funds
Eligibility
Inclusion criteria
Inclusion criteria: 1. Male or female arriving in OT for pelvic-acetabular injury and fracture shaft femur. 2. 18- 60 years of age. 3. ASA Grade I/II patients i.e. with minimal risk of anesthesia as per standard practices.
Exclusion criteria
Exclusion criteria: 1. Signs of infection present. 2. History of being operated within 3 months for any ailment. 3. Any allergy to anesthetic/ local anesthetic drugs. 4. Redo surgery. 5. Patient on immunosuppressant therapy. 6. History of inflammatory disorder. 7. Patients with difficult airway requiring fiber-optic intubation. 8. Contraindication to regional anesthesia i.e.platelet count 1.5 9. Spine pathology present.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Outcome: Influence of different anesthetic techniques on NETosis and their components and on development of SIRS.Timepoint: 3 years | — |
Secondary
| Measure | Time frame |
|---|---|
| 1: In-Vivo quantification of NETs, MPO & Histone at consecutive time points during and after isolated major orthopaedic trauma surgeries. 2: Optimal timing for nonlife-saving surgical intervention after trauma. 3: Damaged tissue healing and repair. 4: Second hit related MOF. 5: Hospital length of Stay. Timepoint: 3 years | — |
Countries
India
Contacts
Public ContactPallavi Tiwari
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed