Comparing smell training and a medicine in the treatment of patients with loss of smell

EFFECTIVENESS OF OLFACTORY TRAINING AND ALPHALIPOIC ACID IN THE TREATMENT OF SEVERE OLFACTORY DYSFUNCTION- A RANDOMIZED CONTROLLED TRIAL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/01/022613

Enrollment

100

Registered

2020-01-06

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R00-R99- Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

Interventions

Intervention1: Alphalipoic acid: All patients fulfilling the inclusion criteria will be asked to fill the Self administered odour questionnaire (SAOQ) and grade the severity of their olfactory loss ba

Eligibility

Inclusion criteria

Inclusion criteria: Patients above 16 years of age History of loss of smell Severe hyposmia or anosmia on evaluation No identifiable cause

Exclusion criteria

Exclusion criteria: Patients below 16 years of age Pregnancy Etiology of smell loss other than post infectious or idiopathic Prior sinus, skull base or brain surgery Cognitive or psychiatric dysfunction Head injury Patients having nasal mass

Design outcomes

Primary

Measure	Time frame
Change in Olfaction test scores (Threshold score, identification score and composite score) post treatment Timepoint: At the end of 3 months	—

Secondary

Measure	Time frame
Change in Visual Analogue Score and Self Administered Odor Questionaire scores post treatmentTimepoint: two and a half years	—

Countries

India

Contacts

Public ContactBerenice Stella B

Christian Medical College

laleevarghese@cmcvellore.ac.in04162283483

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026