A clinical trial to assess the efficacy of the combination of propane, butane and isobutane gases (commercially available as ENDOFROST) to manage a cystic lesion called odontogenic keratocyst that affects the jaw bones

Efficacy of Gas Combination Cryotherapy in the management of Odontogenic Keratocyst of Maxilla and Mandible

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/01/022601

Enrollment

Registered

2020-01-03

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K090- Developmental odontogenic cysts

Interventions

Intervention1: Enucleation of the cyst followed by use of gas combination cryotherapy: The removal of the cysts lining in toto followed by spraying of the cystic cavity with a combination of propane,

Eligibility

Inclusion criteria

Inclusion criteria: Patients with odontogenic keratocyst in the mandible and the maxilla.

Exclusion criteria

Exclusion criteria: Patients with uncontrolled diabetes Cases of recurrence Cases with any pre-existing neurosensory deficit Smokers Pregnant and lactating women

Design outcomes

Secondary

Measure	Time frame
Absence of infection and wound dehiscenceTimepoint: 1 week postoperaively;Absence of ParesthesiaTimepoint: Preoperatively,1 week,3 weeks,1 month,6 months ,12 months and 15 months postoperatively;Absence of recurrence and pathologic fractureTimepoint: 15 months postoperatively;Maintaining vitality of the toothTimepoint: Preoperative, 1 week,3 weeks,1 month,6 months ,12 months and 15 months postoperatively	—

Measure

Time frame

Absence of infection and wound dehiscenceTimepoint: 1 week postoperaively;Absence of ParesthesiaTimepoint: Preoperatively,1 week,3 weeks,1 month,6 months ,12 months and 15 months postoperatively;Absence of recurrence and pathologic fractureTimepoint: 15 months postoperatively;Maintaining vitality of the toothTimepoint: Preoperative, 1 week,3 weeks,1 month,6 months ,12 months and 15 months postoperatively

—

Primary

Measure	Time frame
Bone formationTimepoint: Preoperatively and 15 months Postoperativey	—

Countries

India

Contacts

Public ContactAnjali P Rair

Amrita School of Dentistry

shyamasha@gmail.com8281864886

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026