Health Condition 1: D10- Benign neoplasm of mouth and pharynx Health Condition 2: C00-C14- Malignant neoplasms of lip, oral cavity and pharynx Health Condition 3: D498- Neoplasm of unspecified behavior of other specified sites
Conditions
Interventions
Intervention1:
Biopsy procedure and histopathological grading
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Cytological preparation and evaluation
:
Biopsy procedure and histopathological grading
Incisional biopsies will be taken from the
Sponsors
AIIMS Jodhpur
Eligibility
Inclusion criteria
Inclusion criteria: Patients of premalignant and early malignant oral and oropharyngeal lesions
Exclusion criteria
Exclusion criteria: Patients with known mutation diagnosed tumour syndromes of pre confirmed familial cancer syndromes will be excluded as their molecular progression is already established. Patients not consenting for the study will also be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We expect to find some differential expression of nuclear and micronuclear features such as shape and pattern of nucleus, nuclear staining features, presence and number of AgNOR avid regions and presence, CK-8 immuno-reactivity and number of micronucleus scores in various stages of premalignant and early malignant oral and oropharyngeal lesions which can be further analysed for studying its clinical implications.Timepoint: 0 to 6 months 1 Sample collection 2 Procurement of stains antibodies and detection kit 7 to 18 months 1 Standardization of the staining and IHC protocol 2 Prospective case analysis by staining and IHC 19 to 24 months Compilation of data and submission along with knowledge outcome in terms of a paper | — |
Secondary
| Measure | Time frame |
|---|---|
| A cyto morphological score with a cut off value for malignant changesTimepoint: at 24 months during final analysis | — |
Countries
India
Contacts
Public ContactDr Darwin
AIIMS, Jodhpur
Outcome results
None listed