To study role of dexmedetomidine given in elderly patients undergoing long duration non cardiac surgery under general anesthesia in preventing postoperative confusional state.dexmedetomidine drug provide adequate sedation,pain relief during and after surgery

To study the effect of perioperative dexmedetomidine on postoperative delirium and cognitive dysfunction in elderly patients undergoing major non cardiac surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/12/022478

Enrollment

170

Registered

2019-12-20

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R419- Unspecified symptoms and signs involving cognitive functions and awareness

Interventions

Intervention1: Dexmedetomidine drug: Dexmedetomidine drug is given before induction as loading dose 0.5mcg/kg over ten minutes and in intraoperative period as infusion is given at 0.5mcg/kg/hr until 3

Eligibility

Inclusion criteria

Inclusion criteria: All ASA-I and ASA-II patients, aged 50 years and above of either sex, who are scheduled to undergo elective non cardiac surgery with expected duration of one and half hours or more under general anaesthesia at Indira Gandhi Medical College, Shimla.

Exclusion criteria

Exclusion criteria: 1) Patient refusing consent. 2) ASA grade III and IV. 3) History of schizophrenia, epilepsy or parkinsons disease 4) Visual,hearing , language or other barriers which hampers communication or preoperative delirium assessment. 5) Neurosurgery or traumatic brain injury 6) Severe bradycardia(hr 7) Severe hepatic dysfunction 8) Renal failure 9) Patients where baseline Neecham score is 20 or below it. 10) Patients aged less than 50 years.

Design outcomes

Primary

Measure	Time frame
ï?¼ To see the incidence and severity of postoperative delirium in immediate and late postoperative period o To see any Postoperative cognitive dysfunction in patients after surgeryTimepoint: 1, 2, 3 postoperaive day	—

Secondary

Measure	Time frame
Sedation or Agitation status of the patient by using Richmond Agitation Sedation Scale(RASS)in immediate postoperative periodTimepoint: Richmond Agitation Sedation Scale(RASS)scoring is done in postoperative period at 0mins,15mins,30mins,4hrs ,8hrs,and 12hrs	—

Countries

India

Contacts

Public ContactDr Jyoti Pathania

Indira Gandhi Medical College Shimla

pathaniajyoti7@gmail.com9418120659

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026