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PREVENTION OF HUMAN SPERM DAMAGE DURING STORAGE AT SUB ZERO TEMPERATURE

INVESTIGATING THE UTILITY OF PHARMACOLOGICAL INHIBITION OF ARACHIDONATE 15- LIPOXYGENASE (ALOX15) IN MINIMIZING THE IATROGENIC SPERM DAMAGE CAUSED DURING HUMAN SEMEN CRYOPRESERVATION

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/12/022469
Enrollment
75
Registered
2019-12-20
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Z048- Encounter for examination and observation for other specified reasons

Interventions

Intervention1: 6,11dihydro[1]benzothiopyrano[4,3-b]indole (PD146176): Semen with lipoxygenase inhibitor, Semen with standard sperm freeze media Control Intervention1: Standard sperm freeze media: Stan

Sponsors

DEPARTMENT OF CLINICAL EMBRYOLOGY
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: MEN ATTENDING KASTURBA HOSPITAL INFERTILITY CLINIC , MANIPAL FOR ROUTINE SEMEN ANALYSIS

Exclusion criteria

Exclusion criteria: AZOOSPERMIC PATIENTS

Design outcomes

Primary

MeasureTime frame
TO MINIMIZE THE IATROGENIC SPERM DAMAGE CAUSED DURING HUMAN SEMEN CRYOPRESERVATIONTimepoint: 12.08.2021—

Secondary

MeasureTime frame
It will prevent in-situ damage induced by semen cryopreservationTimepoint: 2 years—

Countries

India

Contacts

Public ContactSHWETA HEGDE

KASTURBA MEDICAL COLLEGE MANIPAL

shubha.u@manipal.edu9480009731

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026