Comparing the effect of growth factor and membrane when used with bone graft material for the treatment of periodontal defects in human.

Comparative of L-PRF and PLA-PGA membrane with hydroxyapatite crystal collagen fibers bone graft in Human Infrabony Defects.

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/12/022466

Enrollment

Registered

2019-12-20

Start date

Unknown

Completion date

Unknown

Last updated

2023-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: L -PRF with hydroxyapatite crystal collagen fibers bone graft.: leucocyte platelet rich fibrin Membrane with hydroxyapatite crystal collagen fiber bone graft will be placed in 13 subj

Eligibility

Inclusion criteria

Inclusion criteria: 1.Presence of at least 1 or 2 radiographically detectable interproximal intrabony osseous defect with probing pocket depth >= 5 mm and clinical attachment loss >= 5 mm following initial therapy. 2.Depth of intraosseous component of the defect >= 3 mm by clinical and radiographic means, which will be confirmed on intrasurgical measurment 3.A radiographic base of the defect at least 3 mm coronal to the apex of the tooth. 4. Presence of at least 3 mm width of keratinized gingiva around test teeth to allow complete soft tissue coverage of the defect.

Exclusion criteria

Exclusion criteria: 1.Evidence of localized aggressive periodontitis. 2.Patients with unacceptable oral hygiene (Plaque Index >1) 3.Smokers (recent history of smoking more than 10 cigarettes /day) or who used any of tobacco products. 4.Study tooth with inadequate endodontic / restorative treatments. 5.Study tooth with mobility exceeding grade II and exhibiting a class III or class IV furcation defect. 6.History of periodontal surgical therapy of the selected quadrant. 7.Pregnant females or lactating mothers. 8.Clinical or radiographic signs of untreated acute infection at the selected site, apical pathology, root fracture, severe root irregularities, cemental pearls, cementoenamel projections not easily removed by odontoplasty, untreated carious lesions at cementoenamel junction (CEJ) or on the root surface.

Design outcomes

Primary

Measure	Time frame
Radiographic Bone Fill in Infrabony Defects at 6 Months Post Surgery. Timepoint: 6 Months	—

Secondary

Measure	Time frame
Gain in Clinical Attachment Level (CAL) Reduction in Probing Pocket Depth (PPD) Timepoint: 6 Months	—

Countries

India

Contacts

Public ContactDr Priyanka Jaiswal

Datta Meghe institute of medical sciences.

priyanka.banode@gmail.com9960713010

Outcome results