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To check the oxidative stress in the fluid of ovaries in women undergoing assisted reproductive techniques and its influence on embryo parameters.

VEGF-A AND TOTAL OXIDATIVE STRESS IN FOLLICULAR FLUID OF PATIENTS UNDERGOING CONTROLLED OVARIAN HYPERSTIMULATION AND EMBRYO DEVELOPMENT

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2019/12/022459
Enrollment
96
Registered
2019-12-20
Start date
Unknown
Completion date
Unknown
Last updated
2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O94-O9A- Other obstetric conditions, not elsewhere classified

Interventions

Control Intervention1: Comparison of embryo growth and development in the case and control group.: The embryo growth and development will be compared on Day 3/Day 5 (as applicable) among the test grou

Sponsors

Arjun Asok
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Established PCOS (Rotterdam Criteria) undergoing COH. Not more than one abortion No known genetic disorders No history of hypertension, DM, seizures, endometriosis.

Exclusion criteria

Exclusion criteria: Above 35 years More than one abortion History of known genetic disorders History of hypertension, DM, seizures, endometriosis.

Design outcomes

Primary

MeasureTime frame
Impaired embryo development on day 3 and day 5 in a follicular fluid environment with more oxidative stressTimepoint: Day 3 of embryo growth. Day 5 of embryo growth.,

Secondary

MeasureTime frame
Embryo development at Day 3 and Day 5 of ART. Biochemical pregnancy as evidenced by a positive beta hCG on Day 14 of transfer, and clinical pregnancy on the sixth week as evidenced by the presence of a gestational sac on ultrasound examination.Timepoint: Day 3, Day 5, Day 14, 6th week

Countries

India

Contacts

Public ContactArjun Asok

Kasturba Medical College

varashree.bs@manipal.edu9901729498

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026